I like Prime or the product made by Hagen. But I have only used them in doing test. For my tanks I do not use anything. I add water in increments when filling my tanks. I run water for 3 minutes and based on my flow rate that is 18 gallons. Then I wait 30 minutes and repeat the process until the tank is full.
150gal- Dovi's; 3 AC 110 P.Filters; 2 AC 110 P.Heads; Eheim 2217,2260
180gal- Managuense; 3 AC 110 P.Filters; 2 AC 110 P.Heads; Eheim 2217,2260; FX5
210gal- Argta,Bifsct,Fnstrtus,Maculcda,Regani,Syns,Zntus; 4 AC P.Filters; 2 AC P.Hds; Eheim 2250,2262; FX5